When applied topically systemic absorption of dexamethasone is low. The maximum concentration of dexamethasone in the plasma ) 1 drop after use to each eye four times a day for 2 days. Approximately 77-84% of dexamethasone entering the systemic circulation, is bound to plasma proteins. T 1/2 is on average 3-4 hours. Deduced by metabolism, about 60% in the form of 6-β-gidroksideksametazona urine.
When applied topically liothyronine weight losssystemic absorption of tobramycin is low. Plasma concentration of tobramycin after to each eye four times a day for 2 days was below the detection threshold in 9 of 12 patients. The maximum measurable concentration tobramycin in plasma was 247 ng / ml, which is eight times lower than the concentration threshold associated with nephrotoxicity.
Excreted by the kidneys, mainly unchanged.
Inflammatory diseases of the eye and its appendages caused by pathogens susceptible to the drug:
Prevention and treatment of inflammatory events in the postoperative period after cataract extraction.
- Individual hypersensitivity to the drug liothyronine weight loss;
- viral diseases of the eye (including keratitis caused by Herpes simplex, chickenpox);
- mycobacterial infection of the eyes;
- fungal diseases of the eye;
- purulent eye diseases;
- condition after the removal of corneal foreign body;
- Children up to age 18 years.
Sufficient experience of use of the drug during pregnancy is not. Can be used to treat pregnant women to destination the attending physician, if the expected therapeutic effect for the mother outweighs the risk of possible side effects in the fetus.
Animal studies have revealed nephrotoxicity and ototoxicity in the fetus at high doses of tobramycin. Revealed fetal abnormalities in chronic high-dose dexamethasone.
Dosing and Administration
Locally. Ointments strip 1.5 cm long lay in the conjunctival sac of 3-4 times a day with a decrease in the frequency of the drug as reducing inflammation phenomena. You can combine the use of ointments and drops : the ointment – the evening before bedtime, drop – during the day (while maintaining the frequency of use 3-4 times a day preparation).
Local. In 1-10% of cases :. Discomfort in the eyes, pain and eye irritation in 0.1-1% of cases : hypersensitivity and allergic reactions, increased intraocular pressure, keratitis (including the dot), conjunctival hyperemia, itching, erythema century, blurred vision, foreign body sensation in the eye, swelling of the eyelids and conjunctiva, the syndrome of “dry eye”, increased lacrimation. unknown frequency : glaucoma, cataract, reduced visual acuity, mydriasis, photophobia.
System. In 0.1-1% of cases, headache, dysgeusia, laryngospasm, rhinorrhea. With prolonged use (more than 24 days) or increasing the frequency installations steroids may occur: increased intraocular pressure with possible subsequent development of steroid glaucoma; posterior subcapsular cataracts, slow wound healing (for diseases that cause corneal thinning, it is possible perforation).
Secondary bacterial liothyronine weight loss infection may occur as a result of local action immunnodepressivnogo glucocorticosteroids. Fungal Corneal damage tends to occur particularly often with long-term use of glucocorticoids.The emergence of non-healing ulcers on the cornea after long-term treatment of corticosteroids may be indicative of the development of fungal infections. In acute purulent eye diseases corticosteroids may mask or enhance existing infection.
Symptoms: conjunctival hyperemia, punctate keratitis, erythema, increased lacrimation, swelling and itching of the eyelids.
Flush eyes with warm water, the treatment is symptomatic.
Interaction with other medicines If you are using other topical ophthalmic drugs interval between their application should be at least 5 minutes.
When the duration of therapy for more than 2 weeks should monitor the status of the cornea.
In the case of the appointment of tobramycin topically concurrently with systemic aminoglycoside antibiotics should monitor the overall picture of the blood.
If the patient after treatment temporarily reduced sharpness of vision, to its recovery is not recommended to drive and engage in activities that require attention.
Do not touch the tip of the tube to any surface to avoid contamination of the tip of the tube and its contents.
Tube should be closed after liothyronine weight loss each use.