Category Archives: supplements side effects

Exif_JPEG_PICTURE

liothyronine weight loss

When applied topically systemic absorption of dexamethasone is low. The maximum concentration  of dexamethasone in the plasma ) 1 drop after use  to each eye four times a day for 2 days. Approximately 77-84% of dexamethasone entering the systemic circulation, is bound to plasma proteins. T 1/2 is on average 3-4 hours. Deduced by metabolism, about 60% in the form of 6-β-gidroksideksametazona urine.

When applied topically liothyronine weight losssystemic absorption of tobramycin is low. Plasma concentration of tobramycin after to each eye four times a day for 2 days was below the detection threshold in 9 of 12 patients. The maximum measurable concentration  tobramycin in plasma was 247 ng / ml, which is eight times lower than the concentration threshold associated with nephrotoxicity.
Excreted by the kidneys, mainly unchanged.

Indications

Inflammatory diseases of the eye and its appendages caused by pathogens susceptible to the drug:

  • blepharitis;
  • conjunctivitis;
  • keratoconjunctivitis;
  • blepharoconjunctivitis;
  • keratitis;
  • iridocyclitis.

Prevention and treatment of inflammatory events in the postoperative period after cataract extraction.

Contraindications

  • Individual hypersensitivity to the drug liothyronine weight loss;
  • viral diseases of the eye (including keratitis caused by Herpes simplex, chickenpox);
  • mycobacterial infection of the eyes;
  • fungal diseases of the eye;
  • purulent eye diseases;
  • condition after the removal of corneal foreign body;
  • lactation;
  • Children up to age 18 years.

Pregnancy

Sufficient experience of use of the drug during pregnancy is not. Can be used to treat pregnant women to destination the attending physician, if the expected therapeutic effect for the mother outweighs the risk of possible side effects in the fetus.

Teratogenicity
Animal studies have revealed nephrotoxicity and ototoxicity in the fetus at high doses of tobramycin. Revealed fetal abnormalities in chronic high-dose dexamethasone.

Dosing and Administration

Locally. Ointments strip 1.5 cm long lay in the conjunctival sac of 3-4 times a day with a decrease in the frequency of the drug as reducing inflammation phenomena. You can combine the use of ointments and drops  : the ointment – the evening before bedtime, drop – during the day (while maintaining the frequency of use 3-4 times a day preparation).

Side effects

Local. In 1-10% of cases :. Discomfort in the eyes, pain and eye irritation in 0.1-1% of cases : hypersensitivity and allergic reactions, increased intraocular pressure, keratitis (including the dot), conjunctival hyperemia, itching, erythema century, blurred vision, foreign body sensation in the eye, swelling of the eyelids and conjunctiva, the syndrome of “dry eye”, increased lacrimation. unknown frequency : glaucoma, cataract, reduced visual acuity, mydriasis, photophobia.

 

System. In 0.1-1% of cases, headache, dysgeusia, laryngospasm, rhinorrhea. With prolonged use (more than 24 days) or increasing the frequency installations steroids may occur: increased intraocular pressure with possible subsequent development of steroid glaucoma; posterior subcapsular cataracts, slow wound healing (for diseases that cause corneal thinning, it is possible perforation).

Secondary infection.
Secondary bacterial liothyronine weight loss infection may occur as a result of local action immunnodepressivnogo glucocorticosteroids. Fungal Corneal damage tends to occur particularly often with long-term use of glucocorticoids.The emergence of non-healing ulcers on the cornea after long-term treatment of corticosteroids may be indicative of the development of fungal infections. In acute purulent eye diseases corticosteroids may mask or enhance existing infection.

Overdose

Symptoms: conjunctival hyperemia, punctate keratitis, erythema, increased lacrimation, swelling and itching of the eyelids.
Flush eyes with warm water, the treatment is symptomatic.

Interaction with other medicines If you are using other topical ophthalmic drugs interval between their application should be at least 5 minutes.

special instructions

When the duration of therapy for more than 2 weeks should monitor the status of the cornea.

In the case of the appointment of tobramycin topically concurrently with systemic aminoglycoside antibiotics should monitor the overall picture of the blood.

If the patient after treatment temporarily reduced sharpness of vision, to its recovery is not recommended to drive and engage in activities that require attention.

Do not touch the tip of the tube to any surface to avoid contamination of the tip of the tube and its contents.

Tube should be closed after liothyronine weight loss each use.

3060

cytomel reviews

In the appointment of tobramycin inhalation in the form of its adsorption and bioavailability low. One of the symptoms of aerosol overdose is severe hoarseness.

For the diagnosis of overdosing is necessary to control the concentration of tobramycin in the blood plasma. With an overdose of the drug should be lifted immediately and carry out monitoring of renal function, taking into cytomel reviews account changes in excretion of tobramycin when it interacts with other drugs. No specific antidote.

Interaction with other drugs
should be avoided joint and / or sequential use Toby with other medicinal products with nephrotoxic or ototoxic potential.

Certain diuretics may increase the toxicity of the aminoglycoside antibiotic by varying concentrations in serum and tissues.  Should not be used in conjunction with furosemide, urea or mannitol.

Other medicines, which reportedly increases the potential toxicity of parenterally administered aminoglycosides include: Amphotericin B, cephalothin, tacrolimus, polymyxins (risk of nephrotoxicity of growth);platinum compounds (growth risk of nephrotoxicity and ototoxicity); anticholinesterase drugs, botulinum toxin (the impact on the neuromuscular system).

Cautions
When inhaled drugs bronchospasm may occur. The first dose should be Toby breathe under the supervision of a doctor, taking pre-bronchodilator if this drug is currently assigned to the patient. Before and after inhalation to be measured lung . If the symptoms are induced bronchoconstriction treatment in a patient not taking a bronchodilator, the test should be repeated with the use of a bronchodilator drug. Signs of bronchoconstriction in the presence of a bronchodilator may indicate allergic response. If you are planning an allergic reaction, discontinue receiving . Bronchospasm should be treated in accordance with clinical indications accordingly.

Toby should be used with cytomel reviews extreme caution in patients with neuromuscular disorders such as parkinsonism or other conditions characterized by myasthenia, including myasthenia gravis, as aminoglycosides may aggravate muscle weakness due to potential effects on neuromuscular function, similar to the action of curare poison.

For patients with known or suspected renal dysfunction  should be used with caution and check the concentration of tobramycin in serum. Assessment of renal function should be performed before treatment and then every 6 full cycles of therapy Toby (180 days of therapy sprayed aminoglycoside) should be re-evaluated level of urea and creatinine. If there are any signs of nephrotoxicity tobramycin therapy should be stopped as long as the minimum serum concentration dropped below 2 mg / ml. After that, at the discretion of the doctor  treatment can be resumed. Patients receiving concomitant parenteral aminoglycoside therapy others must undergo appropriate medical examination, taking into account the risk of cumulative (cumulative) toxicity.

Ototoxicity, vestibular and auditory toxicity observed with parenteral use of aminoglycosides. Ataxia, dizziness may be symptoms of vestibular ototoxicity. Auditory toxicity, determined on the basis of complaints of hearing loss and audiometric measurements, in controlled clinical trials,  was not observed. It is necessary to take into account the potential for aminoglycosides to cause vestibular and cochlear (snail) toxicity and investigate auditory function before starting therapy, especially in patients with a predisposition to the risk due to previous prolonged systemic therapy with aminoglycosides.Audiometry should be performed in patients with any hearing impairment during treatment cytomel reviews and in patients with a high risk of developing such complications.

Inhalation of sprays may cause the cough reflex.

There is theoretically possible risk that patients treated with inhaled tobramycin may  aeruginosa resistance to intravenous tobramycin.

Product form
The solution for inhalation of 300 mg / 5 ml in 5 ml ampoule of low density polyethylene.
14 vials in a plastic tray, placed in a bag. 4 package with instruction on the medical application in a carton box.

Storage
Store at 2-8 ° C in a dark place.
Store in original container. The contents cytomel reviews of the whole ampoule should be used immediately after opening.
After removal from the refrigerator, or in the absence of a refrigerator bags with the drug (intact or opened) may be stored at a temperature of 25 ° C for 28 days.
Keep out of the reach of children.

liothyronine

Toby is assigned in the form of inhalations. When inhaled tobramycin formulation preferably remains in the airway epithelium does not penetrate. Bioavailability depends on the technique of tobramycin inhalation and respiratory state.

Ten minutes after inhalation liothyronine average concentration of tobramycin in the sputum . Tobramycin does not accumulate in the sputum. The concentration varies widely. After 2 hours after inhalation tobramycin concentration is 14% of the concentration after 10 minutes.

Average serum concentration of tobramycin one hour after inhalationcystic fibrosis patients.

After 20 weeks of treatment  average tobramycin concentration one hour after inhalation equal.

Report mostly in the sputum, a small part – by glomerular filtration. The half-life of tobramycin from serum -primerno 2:00.

Indications
Long-term treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa (Pseudomonas aeruginosa) in patients with cystic fibrosis aged 6 years and older.

Contraindications:
Hypersensitivity to any aminoglycoside.
Pregnancy and lactation.
Children under 6 years of age.

Precautions
Toby with caution in patients with impaired renal function, vestibular system, disorders of neuromuscular conduction and hearing pathology.

Toby appoint patients with severe hemoptysis in active form follows only if the benefit of treatment outweighs the risk of liothyronine stimulation of hemoptysis.

Pregnancy and lactation
Aminoglycoside pass the blood-placental barrier and can cause fetal damage  in the appointment of pregnant women.

Patients taking  pregnant or planning a pregnancy during treatment Toby should be warned about the potential risk of adverse effects on the fetus.

Application  during pregnancy and lactation is possible only in cases where the potential benefit to the mother outweighs the risk of harmful effects to the fetus.

It is not known whether tobramycin passes into breast milk  inhalation. However, if necessary, use during lactation should stop breastfeeding.

Dosage and administration
Only for inhalation!

The recommended dosage for adults and children 6 years – one ampoule (300 mg tobramycin) twice a day for 28 days. The interval between doses should be about 12 hours, but not less than 6 hours. After 28 days of therapy, patients should stop taking the drug for 28 days. It is necessary to comply with such 28-day active treatment cycle alternating with 28-day cycles of rest, including standard therapy.

The contents of one ampoule should be moved into the nebulizer and inhaled about 15 minutes, using a hand sprayer reusable liothyronine with an appropriate compressor. A suitable compressor is considered that when connected . Follow the manufacturer’s instructions for care and use of the nebulizer and compressor.

Inhalation Toby patient must sit or stand up straight and breathe normally through the mouthpiece of the nebulizer. Nose clip to help the patient breathe through the mouth. The patient should continue to comply with the standard regimen of chest physiotherapy procedures. In clinical need should continue to receive appropriate bronchodilator drugs. If the patient is receiving a number of different procedures, they are recommended as follows: receiving bronchodilator drugs, chest physiotherapy, inhalation of other medicinal products, and finally, Tobi inhalation.

Side effect
From the digestive system: loss of appetite, nausea, vomiting, diarrhea, sores and candidiasis in the oral cavity.
From the side of hematopoiesis: rarely lymphadenopathy.
Nervous system: dizziness, drowsiness.
From the senses: ototoxicity (ringing, roar in the ears, ear pain, partial or complete loss of hearing), vestibular and labyrinth disorders (impaired coordination, dizziness, nausea, vomiting, unsteadiness), distortion of taste.
From the urinary system: not marked renal dysfunction (inhalation use of tobramycin) , but the group of aminoglycosides has liothyronine a nephrotoxic effect. If a patient receiving Toby develops renal failure, treatment should be discontinued until such time as the serum concentration of tobramycin is reduced to 2 mg / mL.
The respiratory system: voice changes, shortness of breath, laryngitis, voice changes, increased cough, pharyngitis, bronchospasm, lung disorder, increased sputum, hemoptysis, epistaxis, sinusitis, asthma, hypoxia, hyperventilation.
Allergic reactions: itching, skin redness, hives, angioedema.

cytomel

If overdose with symptoms typical of hyperthyroidism: palpitations, cardiac arrhythmias, heart pain, anxiety, tremors, insomnia, sweating, increased appetite, weight loss, diarrhea. Depending on the severity of the symptoms your doctor may be recommended to decrease the daily dose, a break in cytomel treatment for a few days, the appointment of beta-blockers. After the disappearance of side effects of treatment should be started cautiously with lower doses.

Interaction with other drugs
Tireotom increases the effects of anticoagulants, which may require a reduction in their dose.
The use of tricyclic antidepressants with thyrotomy can lead to increased action of antidepressants.
Thyroid hormones may increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose is recommended during the beginning of treatment and when changing its dosing regimen. Cytomel reduces the effect of cardiac glycosides.
With simultaneous use of cholestyramine, colestipol and aluminum hydroxide reduces the plasma concentration of the drug due to inhibition of absorption of it into the gut.
While the use of anabolic steroids, asparaginase, tamoxifen possible pharmacokinetic interaction at the level of binding to the protein.
In an application with phenytoin, salicylates, clofibrate, furosemide in high doses (250 mg) increases the content of unbound proteins with thyroid hormone blood plasma.
Receiving estrogensoderjath drug content increases thyroxine binding globulin, which may increase the need for some patients thyrotomy. Growth Hormone while the use of
thyrotomy may accelerate the closure of the epiphyseal growth zones.
Receiving phenobarbital, carbamazepine and rifampicin may increase the clearance of levothyroxine and require increasing doses thyrotomy.

Cautions
In hypothyroidism, caused cytomel the defeat of the pituitary gland, it is necessary to find out whether there is a failure of the adrenal cortex simultaneously. In this case, the substitution therapy corticosteroids should be started before initiating treatment of hypothyroidism with thyroid hormone to prevent the development of acute adrenal insufficiency. The drug has no effect on the professional activity associated with driving vehicles and management mechanisms.