In an application with phenytoin, salicylates, dikumarol, clofibrate, furosemide in high doses (250 mg) increases the effects cytomel t3 as increases the content of unbound to proteins blood thyroid hormone plasma.
Enhances the effect of anticoagulants, which may require a reduction in their dose.
The use of tricyclic antidepressants cytomel t3 may lead to increased action of antidepressants.
Thyroid hormones may increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose is recommended during the beginning of treatment and when changing its dosing regimen.
While the use of potassium-sparing diuretics Potassium iodide may increase potassium levels in the blood.
Reduces the effect of cardiac glycosides.
At the same time use of cholestyramine phenyl propanoate, colestipol and aluminum hydroxide reduces the plasma concentration of the drug due to inhibition of its absorption in the gut, so Tireokomb “is recommended to take 4-5 hours prior to receiving these drugs.
while the use of anabolic steroids, asparaginase, tamoxifen possible pharmacokinetic interaction at the level of binding with the protein.
Reception estrogensoderjath drug increases levels of thyroxine-binding globulin, which can increase demand for some patients. Somatropin while the use can speed up the closure of the epiphyseal growth zones.
Receiving phenobarbital, carbamazepine and rifampicin may increase levothyroxine clearance and demand increase .
When ischemic heart disease, heart failure or tachyarrhythmias require more frequent monitoring of thyroid hormone levels.
Particular caution should be exercised when administering the drug to elderly patients. The treatment they should be carried out with lower doses. In applying the drug in children with epilepsy, the likelihood of increasing the number of seizures.
Application in patients with diabetes mellitus, diabetes insipidus or adrenal cortical insufficiency may lead to increased severity of these diseases. During this period, requires a careful selection of treatments for these diseases.
In hypothyroidism, caused the defeat of the pituitary gland, it is necessary to find out whether there is a failure of the adrenal cytomel t3 cortex simultaneously. In this case, the substitution therapy corticosteroids should be started before initiating treatment of hypothyroidism with thyroid hormone to prevent the development of acute adrenal insufficiency.
The drug has no effect on the professional activity associated with driving vehicles and management mechanisms.