If overdose with symptoms typical of hyperthyroidism: palpitations, cardiac arrhythmias, heart pain, anxiety, tremors, insomnia, sweating, increased appetite, weight loss, diarrhea. Depending on the severity of the symptoms your doctor may be recommended to decrease the daily dose, a break in cytomel treatment for a few days, the appointment of beta-blockers. After the disappearance of side effects of treatment should be started cautiously with lower doses.
Interaction with other drugs
Tireotom increases the effects of anticoagulants, which may require a reduction in their dose.
The use of tricyclic antidepressants with thyrotomy can lead to increased action of antidepressants.
Thyroid hormones may increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose is recommended during the beginning of treatment and when changing its dosing regimen. Cytomel reduces the effect of cardiac glycosides.
With simultaneous use of cholestyramine, colestipol and aluminum hydroxide reduces the plasma concentration of the drug due to inhibition of absorption of it into the gut.
While the use of anabolic steroids, asparaginase, tamoxifen possible pharmacokinetic interaction at the level of binding to the protein.
In an application with phenytoin, salicylates, clofibrate, furosemide in high doses (250 mg) increases the content of unbound proteins with thyroid hormone blood plasma.
Receiving estrogensoderjath drug content increases thyroxine binding globulin, which may increase the need for some patients thyrotomy. Growth Hormone while the use of
thyrotomy may accelerate the closure of the epiphyseal growth zones.
Receiving phenobarbital, carbamazepine and rifampicin may increase the clearance of levothyroxine and require increasing doses thyrotomy.
In hypothyroidism, caused cytomel the defeat of the pituitary gland, it is necessary to find out whether there is a failure of the adrenal cortex simultaneously. In this case, the substitution therapy corticosteroids should be started before initiating treatment of hypothyroidism with thyroid hormone to prevent the development of acute adrenal insufficiency. The drug has no effect on the professional activity associated with driving vehicles and management mechanisms.