When administered levothyroxine liothyronine sodium is absorbed almost exclusively in the upper small intestine. Absorbed 80% of the dose of the drug. Food intake reduces the absorption of levothyroxine. Maximum serum concentration is reached approximately 5-6 hours after ingestion. After absorption of more than 99% of the drug is bound to serum proteins (thyroxine-binding globulin, thyroxine binding prealbumin, and albumin). In various tissues occurs monodeyodirovanie levothyroxine about 80% to form triiodothyronine and inactive ingredients. Thyroid hormones are metabolized mainly in the liver, kidney, brain and muscles. A small amount of the drug undergoes deamination and decarboxylation as well as sulfuric acid and conjugated with glucuronic acid (in the liver).The metabolites are excreted in the urine and bile. The half-life of levothyroxine is 6-7 days. When thyrotoxicosis half-life is shortened to 3-4 days, and hypothyroidism is extended to 910 days. Liotironin . Absorption ingestion – 95% (4 hours). Relationship to plasma proteins – high. The half – 2.5 days.
- hypothyroidism liothyronine sodium;
- euthyroid goitre;
- as replacement therapy and for the prevention of goiter recurrence after resection of the thyroid gland;
- thyroid cancer (after surgery);
- Graves’ disease: after reaching tireostatikami euthyroid state (a combination therapy).
- Individual hypersensitivity to the drug;
- untreated thyrotoxicosis;
- acute myocardial infarction, angina III-IV functional class;
- acute myocarditis;
- untreated adrenal insufficiency.
should be prescribed the drug for diseases of the cardiovascular system: ischemic heart disease (atherosclerosis, angina pectoris I-II functional class, history of myocardial infarction), heart failure, hypertension, tachycardia, tachyarrhythmia; diabetes, severe long-existing hypothyroidism, liothyronine sodium malabsorption syndrome (may require dose adjustment); elderly patients.
Use during pregnancy and lactation
During pregnancy and breast-feeding therapy with thyroid hormones, appointed about hypothyroidism, should be continued. During pregnancy, you want to increase the dose of the drug due to increased levels of thyroxine-binding globulin.
The use of the drug during pregnancy in combination with tireostatikami contraindicated, as may be necessary to increase the dose thyreostatics. Since tireostatiki unlike levothyroxine can cross the placenta, the fetus may develop hypothyroidism.
The amount of thyroid hormone secreted by breast milk during lactation (even during the treatment with high doses of the drug), is insufficient to cause any disorders in children. However, breast-feeding period, the drug should be taken with caution, strictly within the recommended doses under medical supervision.
Dosage and administration
The daily dose is determined individually, depending on indications. Hypothyroidism. Adults : Treatment starts with 1 tablet thyrotomy a day, then the dose may be increased to 1 tablet every 2-4 weeks until the maintenance daily dose is 2-5 tablets. Children : the selection of doses for long-term care into account body weight, height, and the child’s body surface. The average recommended maintenance dose is 2-2½ tablets a day thyrotomy. Euthyroid goiter . Adults : initial dose of 1-2 tablets per day, maintenance dose -3-6 tablets a day. Teenagers : the initial dose is 1-1½ tablets a day, maintenance dose – 2½-3½ tablets a day. Children : appoint ½-1 tablet per day. Preventing relapse after surgical treatment of goiter. Adults appoint 2-3 tablets a day. after surgery for cancer of the thyroid gland . The initial dose is 3 tablets a day, maintenance dose -. 6 tablets per day daily dose taken once chime, at least 30 minutes before breakfast without chewing and drinking plenty of fluids. The drug should be carried out regularly.The duration of treatment is determined by the form of the disease. Typically, in hypothyroidism and after about thyroidectomy thyroid cancer treatment liothyronine sodium is carried out over a lifetime. Duration of treatment with euthyroid goitre, as well as for the prevention of goiter recurrence after surgical treatment ranged from months or years to use throughout their lives.
Common side effects are not observed When used properly, under the supervision of a physician.
There may be an allergic reaction, liothyronine sodium the progression of heart failure and angina.