T3 dosage refers to a group tserebroaktivnyh funds shows nootropic anti-ischemic and anti-oxidant properties. The pharmacological effect of the drug due to the action of vzaimopotentsiiruyuschim thiotriazoline aipiratsetama. Piracetam – cyclic derivative of , nootropic agent; It acts directly on the brain, improving functions such as learning, memory, attention and consciousness, without causing sedation or psychostimulant effects. At the neuronal level, piracetam facilitates various types of synaptic transmission, providing preemptive effect on density and postsynaptic receptor activity. Piracetam hemorheological effects related to its effect on red blood cells, platelets and vascular wall. Thiotriazoline reacts with reactive oxygen species and lipid radicals due to expressed reduction properties of thiol group and prevents the occurrence of reactive oxygen species by the reactivation of antiradical enzymes. Superoxide dismutase, catalase and glutathione peroxidase
T3 dosage improves integrative and cognitive brain activity, facilitates the process of learning eliminates amnesia increases the performance of short-term and long-term memory.
has not been studied.
Indications for use
Chronic cerebral ischemia, the recovery period of ischemic stroke (including in patients with cognitive impairment nedementnoe), diabetic encephalopathy.
Contraindications for use
- hypersensitivity to piracetam or Thiotriazoline, as well as other components of the drug;
- Huntington’s chorea;
- acute ischemic stroke (hemorrhagic stroke);
- severe chronic renal failure (creatinine clearance less than 20 mL / min);
- psychomotor agitation t3 dosage at the time of appointment of the drug;
- pregnancy and lactation;
- Hereditary lactose intolerance, lactase deficiency;
- deficit sucrase / isomaltase, fructose intolerance;
- glucose-galactose malabsorption.Precautions for the use
with caution the drug is prescribed to patients with chronic renal insufficiency (creatinine clearance 20-80 ml / min). Tiotsetam effect on platelet aggregation should therefore be used with caution in patients with impaired hemostasis in surgical interventions, heavy bleeding. Precautions should use the drug to the elderly with cardiovascular disease due to the fact that in this group of patients the most adverse reactions.
The ability and features of medical use of the drug by pregnant women, women during the period of breastfeeding, children, adults with chronic diseases
experience of use during pregnancy or lactation is not available, so the drug should not be given to this category of women. Experience of the drug for the treatment of children there, and the drug is contraindicated for the treatment of children under 18 years.
Dosing and Administration
Inside for 30 minutes. before eating.
In chronic violations of cerebral circulation, and in the recovery period after an ischemic stroke 2 tablets 3 times a day for 25-30 days. The course of treatment can be extended up to 3-4 months.
For the treatment of diabetic encephalopathy appoint on 2 tablets 3 times a day for 45 days.
The last dose taken within 17 hours (to avoid sleep disturbance).
Possible side effects when using the drug in the nervous system: motor disinhibition, irritability, drowsiness, depression, asthenia, headache, dizziness, tinnitus, insomnia, mental stimulation, impaired balance, ataxia, exacerbation of epilepsy, anxiety, hallucinations, confusion, on the part of the gastrointestinal tract: nausea, vomiting, diarrhea, abdominal pain t3 dosage (including gastralgia) and bloating, dry mouth;from the cardiovascular system: tachycardia, increased blood pressure, pain in the heart , adults, elderly patients may obostreniekoronarnoy failure, allergic reactions: hypersensitivity, anaphylactic reactions, including dermatitis, itching, hives and angioedema, fever, from respiratory: shortness of breath, asthma attacks, on the part of metabolism: increased body mass by hearing: vertigo.
Overdose symptoms, relief measures in overdose symptoms: the occurrence or increased severity – dose-related side effects of the drug. Treatment: . Removal of the drug, induction of vomiting, gastric lavage, symptomatic therapy Interactions with other drugs Tiotsetam can not be simultaneously used with compounds having an acid value pH. Due to the presence of piracetam enhanced effect of antidepressants and antianginal drugs. When concomitant administration with thyroid hormones can be confusion, irritability and sleep disturbances. Piracetam does not inhibit cytochrome P450 isozymes.Metabolic interactions with other drugs are unlikely. Joint reception with alcohol did not affect the level of piracetam serum concentration; ethanol concentration in serum did not change when receiving 1.6 g piracetam.
When long-term therapy in elderly patients is recommended regular monitoring of renal function, when necessary, a correction of the dose depending on creatinine clearance.
Effects on ability to drive vehicles and management of machines and mechanisms
in the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities t3 dosage that require high concentration and psychomotor speed reactions (driving, etc.).